Here’s our full breakdown of CBD and it’s wonderful medicinal benefits.
CBD & Essential Oils: Better Together!
Cannabidiol, better known as CBD, may be one of the most broadly therapeutic plant extracts of our time. Along with its lengthy list of therapeutic properties, it comes with a major bonus for aromatherapists. Essential oils, in fact, significantly potentiate CBD’s therapeutic benefits.* From a natural therapeutic perspective, there is no question that CBD and essential oils together may very well support the body’s healing in a great number of ways.
CBD is the primary constituent of the CO2 or alcohol extract of hemp (Russo, 2011), along with many other cannabinoids. While the the THC content is negligible, because it is thought that most — if not all — cannabinoids have beneficial properties, we use a ‘full spectrum’ hemp extract in our formulas, rather than inexpensive and/or synthetic CBD isolates.
In the eyes of most legal entities, and the reason we can offer it through our website, is it is legal because it is simply a product of industrial hemp (Cannabis sativa with a THC content of less than 0.3%) grown in a number of States throughout the USA (including Colorado, where we source our certified organic CBD).
The importation of hemp products from Europe and Canada has been legal for some time, which has allowed a large amount of scientific research to be performed on CBD itself: well over 1,500 peer-reviewed scientific articles have been published (Henein M, 2016) finding CBD a potentially beneficial treatment for a host of common aliments including all varieties of inflammation, pain management, treatment of cancers, prevention of Alzheimer’s, relief from anxiety, eradication of acne, epilepsy, and the list goes on.
Breifly, FYI: prices have been slashed on all our CBD formulas, as we have partnered with a certified organic hemp grower and extractor in our home state of Colorado. Also, see our Sales and Specials page on how to receive a bottle of the blend of your choice, free with your order.
How CBD Works: The Endocannabinoid Messenger System
To understand how CBD exerts its effects, it is first important to understand our body’s endocannabinoid system (ECS). The ECS is an entire system within the human (and most animals) just like the respiratory or digestive system. It is made up of of the endocannabinoid molecules made by the body itself (yes, our bodies make their own cannabinoids, just like the Cannabis plant!), the receptors for these molecules, and the enzymes which create and break down the endocannabinoids.
All these molecules, receptors and enzymes, plus the affected neurons and neural pathways, and the cells in which the endocannabinoids are synthesized and broken down, comprise the total of the ECS (Grotenhermen, 2012).
What is a ‘Messenger System’?
Cells communicate with one another by releasing molecules that are intercepted by receivers on the surfaces of other cells. There are two known endocannabinoid molecules that our body makes: Anandamide, also known as “the bliss chemical” (“Ananda” is the Sanskrit word for “bliss”), and 2-arachidonoylglycerol or simply ‘2-AG’.
Cannabinoid receptors are protein structures to which the cannabinoids bind. The two cannabinoid receptors are CB1, found primarily in the brain, central and peripheral nervous system and organs, and CB2, found primarily in the immune system (Grotenhermen, 2012).
CBD Enhances the Action of Our Own “Bliss Chemical”
One of CBD’s primary means of affecting our bodies is by increasing the availability and activity of anandamide – again, anandamide is a cannabinoid made by our own body. CBD make anandamide more available and active by suppressing the enzyme ‘FAAH’, which is responsible for breaking down all cannabinoids in the body.
Anandamide has a naturally short half-life, typically on the order of a few minutes (Pacher, 2016). Meaning once the body produces it, it only stays around for a little while to exert its actions. CBD, by preventing anandamide’s breakdown, it remains active for a significantly longer period of time.
Anandamide is Good for Us, and CBD Keeps it Active in Our Body
Anandamide binds to both CB1 and CB2 receptors, regulating of appetite, motivation and pleasure, as well as affecting the immune system (Project CBD, 2016). Anandamide may also inhibit human breast cancer cell proliferation, lower blood pressure and heart rate, lower ocular blood pressure, and inhibit smooth muscle contraction in the gastrointestinal tract – also known as ‘belly aches’ (Petrocellis, 1998).
By Extending the Life of Ananadamide, CBD Acts Like Nature’s Tylenol®
Anandamide has been shown to decrease the perception of pain (Clapper, 2010). Acetaminophen (Tylenol®) is a widely used pain reliever which has no anti-inflammatory activity, so it does not reduce pain in the same anti-inflammatory way that aspirin or ibuprofen do. Rather, Tylenol® produces analgesic effects by forming AM404, a molecule which inhibits re-uptake and degradation of anandamide (Bertolini, 2006). This can be likened to the way CBD does the same thing, just by a different biochemical pathway.
CBD Also Stimulates the Release of 2-AG, Our Other Endocannabinoid
2-AG activates both CB1 and CB2 receptors, while at the same time opposing the action of THC at the CB1 receptor. The physiological effects of 2-AG are not well understood, though it is also hypothesized to play an important role in regulation of appetite, immune function and pain perception (Sensi Seeds, 2013).
CBD Together with Essential Oils: The “Entourage Effect” (or ‘Why You Want Essential Oils with your CBD!)
Terpenes are aromatic molecules produced by virtually every member of the plant kingdom and are found in most essential oils. The terpene ‘linalool’, for example, is a primary constituent of lavender (Lavendula angustifolia), imparting much of its characteristic scent and therapeutic properties (Koulivand P, 2013).
Of the 150+ aromatic compounds (essential oil constituents) found in Cannabis sativa, about 140 are terpenes. Hemp essential oil is very rich in the terpenes myrcene and β-caryophyllene in particular (Zgliczynska M, 2016; Novak J, 2001). Like CBD itself, both have a wealth of scientific research supporting their health benefits (Russo B, 2011).
Cannabinoids + Essential Oil Terpenes = “The Entourage Effect”
Scientists call this synergy – the action of both Cannabinoids and all the terpenes at the same time – “the entourage effect”. By using this term, they are implying that terpenes and cannabinoids together may have greater total health benefits than the additive effect of using either alone. Meaning CBD and terpenes ‘multiply’ the action of each other.
Ananda’s CBD Formulas: CBD, Terpenes and Much More
We offer several formulas to take advantage of this synergy. Every blend we make includes ingestible hemp essential oil, and most include a complex, perfect mixture of CBD and ingestible essential oils based on the properties of the essential oils and what you may be seeking CBD for.**
Every blend is precisely made to include 1mg CBD per every 2 drops. On each CBD formula’s page, you’ll see the number of milligrams of CBD in each bottle, and the number of drops as well. (They do differ slightly because each essential oil has a unique drop size).
Our owner and chief formulator has spent significant time in developing these, following the scientific research on CBD and the included essential oils and CO2 extracts. Again, these are all safe-to-ingest essential oils/CO2’s at the concentrations included in each blend. Thanks for reading!
**CBD ‘100’ contains only CBD, MCT Coconut Oil & Rosemary Antioxidant, for anyone who has needs for CBD by itself.
Bertolini A, Ferrari A, Ottani A, Guerzoni S, Tacchi R, Leone S. (2006). Paracetamol: New Vistas of an Old Drug. CNS Drug Reviews. 12.3-pro4, p250-275.
Clapper J R, Moreno-Sanz G, Russo R, Guijarro A, Vacondio F, Duranti A, Tontini A, Sanchini S, Sciolino N R, Spradley J M, Hohmann A G, Calignano A, Mor M, Tarzia G, Piomelli D. (2010). Anandamide Supresses Pain Initiation through a Peripheral Endocannabinoid Mechanism. Nature Neuroscience. 13 (10), p1265-1270.
Grotenhermen F. (2012). The Therapeutic Potential of Cannabis and Cannabinoids. Dtsch Arztebl Int. 109(PMC3442177), p495-501. doi:10.3238/arztebl.2012.0495.
Koulivand P, Ghadiri M, Gorji A. (2013). Lavender and the Nervous System. Evidence Based Complementary and Alternative Med. Available: http:// dx.doi.org/10.1155/2013/681304. Last accessed: 4 Jan. 2017.
Pacher P, Bátkai S, Osei-Hyiaman D, Offertáler L, Liu J, Harvey-White J, Brassai A, Járai Z, Cravatt B F, Kunos G. (2005). Hemodynamic Profile, Responsiveness to Anandamide, and Baroreflex Sensitivity of Mice Lacking Fatty Acid Amide Hydrolase. AJP Heart and Circulatory Physiology. 289 (2), H533-41.
Petrocellis L, Melck D, Palmisano A, Bisogno T, Laezza C, Bifulco M, Di Marzo V. (1998). The Endogenous Cannabinoid Anandamide Inhibits Human Breast Cancer Cell Proliferation. Proceedings of the National Academy of Sciences. 95 (14), p8375-8380.
Project CBD. (2016). How CBD Works. Available: https://www.projectcbd.org/how-cbd-works. Last accessed 26 Oct. 2016
Russo E. (2011). Taming THC: potential Cannabis synergy and phytocannabinoid-terpenoid entourage effects. British Journal of Pharmacology. 163 (7), p1344-1364.
FOOD AND DRUG ADMINISTRATION (FDA) DISCLOSURE