Here’s our full breakdown of CBD and it’s wonderful medicinal benefits.
|CBD ‘DeFlame’ is our newest CBD formulation, which we’re very, very excited about. It has a wealth of ingredients researched for their anti-inflammatory properties, as is CBD itself*…this incredible blend contains:|
What is CBD and how does it work?
Briefly, CBD (or ‘cannabidiol’) is one of over 100 identified cannabinoids found in Cannabis sativa, and perhaps most importantly for us, it is the most abundant cannabinoid found in ‘industrial’ hemp (and for this reason, is legal in all 50 states).
CBD CO2-extract concentrate contains less than 1% THC, and has no psychoactive properties. It is safely given to children to reduce the frequency of epileptic seizures and is not known to produce false-positives in urine drug screens.
CBD, unlike the psychoactive cannabinoids, does not interact with the CB1 receptors of our body’s own endo-cannabinoid system.
Our bodies do make their own cannabinoids, and much of CBD’s actions result from its inhibition of the enzyme which naturally breaks these down – so our body’s own cannabinoids (ex. ‘anandamide’) have a stronger, longer lasting effect.
What research supports CBD’s use of inflammatory conditions?
CBD has been positively researched for a very wide variety of potential health benefits (see the complete list here)…below is an excerpt specifically relating to its anti-inflammatory properties:
- Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress (PubMed)
- The endocannabinoid system: an emerging key player in inflammation (PubMed)
- Anti-inflammatory role of cannabidiol and O-1602 in cerulein-induced acute pancreatitis in mice(PubMed)
- Cannabinoids, endocannabinoids, and related analogs in inflammation (PubMed)
- Cannabidiol, a non-psychotropic plant-derived cannabinoid, decreases inflammation in a murine model of acute lung injury: role for the adenosine A(2A) receptor (PubMed)
- Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors(PubMed)
- Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis (PubMed)
- Diabetic retinopathy: Role of inflammation and potential therapies for anti-inflammation (PubMed)
- Cannabidiol reduces Aβ-induced neuroinflammation and promotes hippocampal neurogenesis through PPARγ involvement (PubMed)
- Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption (PubMed)
- Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation (PubMed)
- Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation, and cell death (PubMed)
- Cannabinoids in clinical practice (PubMed)
How does CBD work with anti-inflammatory constituents naturally found in essential oils and CO2 extracts?
In this previous post, we looked at the synergistic actions of terpenes and CBD. Scientific research has found that the primary constituents in Hemp and Lavender essential oils are terpenes which act directly on our own endocannabinoid system.1
Hemp essential oil is rich in myrcene, noted to potentially relieve pain and ease aching muscles due to its anti-inflammatory actions. Hemp’s second most abundant constituent is beta-caryophyllene, also noted for its anti-inflammatory properties.
Lavender essential oil has been thoroughly researched for its many positive effects when ingested, and in the study: “Antioxidant, analgesic and anti-inflammatory effects of lavender essential oil” (published in An Acad Bras Cienc. 2015 Aug;87(2 Suppl 0):1397-1408), the authors conclude “The results of this study reveal (in vivo) the analgesic and anti-inflammatory activities of LEO (lavender essential oil) and demonstrates its important therapeutic potential.”
Turmeric CO2 extract is high in compounds known as turmerones, and Ginger CO2 is high in gingerols. These compounds have been positively evaluated for both their anti-inflammatory and pain-relieving properties in a number of studies. In the Indian Journal of Pharmacology, researchers published “An evaluation of antioxidant, anti-inflammatory, and antinociceptive activities of essential oil from Curcuma longa L.” (2011 Sep;43(5):526-31) and “Antioxidant, anti-inflammatory and antinociceptive activities of essential oil from ginger” (2013 Jan-Mar;57(1):51-62). Extracts of both Turmeric and Ginger were found to significantly inhibit inflammation, as well as have antinociceptive (reducing the sensation of pain) properties.
As with all our CBD formulas, the amount of CBD can be precisely measured: Each blend contains 1mg CBD (cannabidiol) per every 2 drops. There are a total of 83mg CBD in 5ml, 248mg in 15ml, and 496 in 30ml.
For more on the science of terpenes and CBD, see…Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. Ethan B. Russo. Br J Pharmacol. 2011 Aug; 163(7): 1344–1364.*