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K-9 Tincture

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Our ‘K-9’ formula has been specially balanced with your pets in mind. This is Cannabidiol CO2 extract from industrial hemp plant based in MCT Coconut oil infused with hemp essential oil. This hemp essential oil with CBD provides the full effect of the hemp plant without any psychoactive THC present. We also add Rosemary antioxidant to preserve freshness.

It is pet safe and has been shown to have tremendous results with dogs!

This tincture contains 1mg of CBD per 2 drops.

 

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$14.90$200.87

Properties

Product Description

CBD K9 is a curated and specialized formulation that consists of carbon-dioxide (CO2) extracted cannabidiol extract, hemp essential oil, medium-chain triglyceride (MCT) coconut oil and rosemary antioxidant.

Studies on CBD and Canines:

Dogs have a higher density of cannabinoid receptors in their brains as opposed to humans [7] and the literature has just begun to reveal studies that have been scoped to researching the effects of CBD on our canine friends. Indeed, this endocannabinoid system that is present in both humans and other mammals, is intimately involved in the regulation of neurotransmission, immunomodulation, and neuroprotection. The activation of these receptors have valuable therapeutic effects as discussed above. Dogs have 2 types of cannabinoid receptors – CB1 and CB2, which readily bind CBD compounds that are ingested or inhaled [8].

One recent study in 2018 aimed to evaluate the safety and performance of a CBD based oil on dogs with osteoarthritis – that is, a degenerative disease of the joints that can cause pain and stiffening. The researchers subjected the dogs to 2 and 8mg/kg of this oil and found an increased comfort and activity in the dogs, with no observable side-effects [9].

Another animal study in 2017 showed that activating the CB1 receptors in animals resulted in anti-convulsant effects – further supporting the neuroprotective effects of CBD extract [10].

For pet-owners who are still concerned about CBD toxicity in canines, despite recent evidence suggesting its safe and therapeutically effective effects, don’t worry! A recent study evaluated the pharmacokinetics (that is, the metabolism and excretion of a drug) of CBD administered in 3 different ways to healthy dogs – topical cream, ingested oil beads and ingested infused oil. Higher systemic concentrations of CBD were found in dogs that had consumed the CBD-infused oil orally; and even then, no observable adverse effects were noted [11].

Safety & Usage

Always speak to your Veterinarian before starting your pet on a new regimen. Generally speaking, we recommend using a range of drops depending on your pet's weight.

We recommend starting with 3-5 mg (6-10 drops) for a medium sized dog (40-60lbs), and ramping up from there to get the desired result.

With bigger dogs, higher doses could be used, and with smaller dogs lower quantities would be a good place to start.

Warning: Keep out of reach of children.

References

1. Diaz-Reinoso, B., et al., Supercritical CO2 extraction and purification of compounds with antioxidant activity. J Agric Food Chem, 2006. 54(7): p. 2441-69.
2. Perrut, M., Supercritical Fluid Applications: Industrial Developments and Economic Issues. Vol. 39. 2000.
3. Foster, N., et al., Processing Pharmaceutical Compounds Using Dense Gas Technology. Industrial & Engineering Chemistry Research, 2003. 42(25): p. 6476-6493.
4. Bergamaschi, M.M., et al., Safety and side effects of cannabidiol, a Cannabis sativa constituent. Curr Drug Saf, 2011. 6(4): p. 237-49.
5. Olah, A., et al., Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes. J Clin Invest, 2014. 124(9): p. 3713-24.
6. Hampson, A.J., et al., Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants. Proceedings of the National Academy of Sciences of the United States of America, 1998. 95(14): p. 8268-8273.
7. Gyles, C., Marijuana for pets? The Canadian veterinary journal = La revue veterinaire canadienne, 2016. 57(12): p. 1215-1218.
8. Chaperon, F. and M.H. Thiebot, Behavioral effects of cannabinoid agents in animals. Crit Rev Neurobiol, 1999. 13(3): p. 243-81.
9. Gamble, L.-J., et al., Pharmacokinetics, Safety, and Clinical Efficacy of Cannabidiol Treatment in Osteoarthritic Dogs. Frontiers in veterinary science, 2018. 5: p. 165-165.
10. Rosenberg, E.C., P.H. Patra, and B.J. Whalley, Therapeutic effects of cannabinoids in animal models of seizures, epilepsy, epileptogenesis, and epilepsy-related neuroprotection. Epilepsy & behavior : E&B, 2017. 70(Pt B): p. 319-327.
11. Bartner, L.R., et al., Pharmacokinetics of cannabidiol administered by 3 delivery methods at 2 different dosages to healthy dogs. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 2018. 82(3): p. 178-183.
12. Russo, E.B., Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. Br J Pharmacol, 2011. 163(7): p. 1344-64.
13. Nissen, L., et al., Characterization and antimicrobial activity of essential oils of industrial hemp varieties (Cannabis sativa L.). Fitoterapia, 2010. 81(5): p. 413-9.
14. Wang, Y., et al., Medium Chain Triglycerides enhances exercise endurance through the increased mitochondrial biogenesis and metabolism. PloS one, 2018. 13(2): p. e0191182-e0191182.
15. Lee, E.J., et al., Lipid-Lowering Effects of Medium-Chain Triglyceride-Enriched Coconut Oil in Combination with Licorice Extracts in Experimental Hyperlipidemic Mice. J Agric Food Chem, 2018. 66(40): p. 10447-10457.
16. Altinier, G., et al., Characterization of topical antiinflammatory compounds in Rosmarinus officinalis L. J Agric Food Chem, 2007. 55(5): p. 1718-23.
17. Bernardes, W.A., et al., Antibacterial activity of the essential oil from Rosmarinus officinalis and its major components against oral pathogens. Z Naturforsch C, 2010. 65(9-10): p. 588-93.

FDA Disclosure

This product is not for use by or sale to persons under the age of 18. This product should be used only as directed on the label. It should not be used if you are pregnant or nursing. Consult with a physician before use if you have a serious medical condition or use prescription medications. A Doctor's advice should be sought before using this and any supplemental dietary product. All trademarks and copyrights are property of their respective owners and are not affiliated with nor do they endorse this product. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. By using this site you agree to follow the Privacy Policy and all Terms & Conditions printed on this site. Void Where Prohibited By Law.

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